Administration of Streptomycin into Inner Ear through Round Window.
نویسندگان
چکیده
منابع مشابه
Analysis of gentamicin kinetics in fluids of the inner ear with round window administration.
HYPOTHESIS That a theoretical basis for quantifying drug distribution in the inner ear with local applications can be established. BACKGROUND As methods of local drug delivery to the inner ear gain wider clinical acceptance it becomes important to establish how drugs are distributed in the ear as a function of time and for different delivery methods. METHODS The time course of gentamicin co...
متن کاملUnderstanding the translocation mechanism of PLGA nanoparticles across round window membrane into the inner ear: a guideline for inner ear drug delivery based on nanomedicine
Background The round window membrane (RWM) functions as the primary biological barrier for therapeutic agents in the inner ear via local application. Previous studies on inner ear nano-drug delivery systems mostly focused on their pharmacokinetics and distribution in the inner ear, but seldom on the interaction with the RWM. Clarifying the transport mechanism of nanoparticulate carriers across ...
متن کاملPharmacokinetic Considerations of Local Drug Delivery to the Inner Ear by Round Window Application
Although there is increasing interest in the local delivery of drugs to the inner ear by applying them to the round window (RW) membrane, most drug application protocols have been empiricallybased. As a result, consequences of changes in delivery method, applied drug concentration or even small alterations in treatment protocols have been difficult to predict. Since direct measurements of drug ...
متن کاملEnhanced local bioavailability of single or compound drugs delivery to the inner ear through application of PLGA nanoparticles via round window administration
In this paper, the potential of poly(D,L-lactide-co-glycolide acid) (PLGA) nanoparticles (NPs) for carrying single or compound drugs traversing the round window membrane (RWM) was examined after the round window (RW) administration of different NPs to guinea pigs. First, coumarin-6 was incorporated into PLGA NPs as a fluorescent probe to investigate its ability to cross the RWM. Then, PLGA NPs ...
متن کاملSurgical method for virally mediated gene delivery to the mouse inner ear through the round window membrane.
Gene therapy, used to achieve functional recovery from sensorineural deafness, promises to grant better understanding of the underlying molecular and genetic mechanisms that contribute to hearing loss. Introduction of vectors into the inner ear must be done in a way that widely distributes the agent throughout the cochlea while minimizing injury to the existing structures. This manuscript descr...
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ژورنال
عنوان ژورنال: Practica Oto-Rhino-Laryngologica
سال: 1974
ISSN: 1884-4545,0032-6313
DOI: 10.5631/jibirin.67.1173